Methyl 2-methyl-7-nitro-2,3-dihydrobenzofuran-4-carboxylate → Methyl 7-amino-2-methyl-2,3-dihydrobenzofuran-4-carboxylate

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Reaction Steps

Methyl 2-methyl-7-nitro-2,3-dihydrobenzofuran-4-carboxylate 30a (100 mg, 0.42 mmol) was dissolved in 20 mL of methanol followed by the addition of palladium/carbon (10 mg, 10%), filled with hydrogen for three times. The reaction solution was stirred for 12 hours and filtered. The filtrate was concentrated under reduced pressure to obtain the title compound methyl 7-amino-2-methyl-2,3-dihydrobenzofuran-4-carboxylate 30b (80 mg, yield: 91.0%) as a colorless oil liquid.

Provenance & Evidence