Hydrochloric Acid → HCID 68107395, compound

Participants

Reaction Steps

7-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-methyl-2,3-dihydrobenzofuran-4-carboxylate 30c (100 mg, 0.21 mmol) and 1 M lithium hydroxide solution were dissolved in 50 mL of the mixture solvent of methanol and tetrahydrofuran (V/V=1:1). The reaction solution was stirred for 12 hours followed by the addition of 1 M hydrochloric acid to adjust pH to 6 to 7. The resulting solution was concentrated under reduced pressure. The residue was added dropwise with 1 M lithium hydroxide solution to adjust pH to 3 to 4 and extracted with ethyl acetate (30 mL×3). The combined organic phase was concentrated under reduced pressure to obtain the title compound 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-methyl-2,3-dihydrobenzofuran-4-carboxylic acid 30d (90 mg, yield: 95.0%) as a white solid.

Provenance & Evidence