反应详情

α-Hydroxypalmitic acid (3.2 g) was dissolved in pyridine (15 ml), and palmitoyl chloride (3.3 g) was added thereto at 0° C. The resulting mixture was allowed to stand overnight at room temperature. The reaction mixture was poured into water and the aqueous solution was stirred at room temperature for 1 hour, followed by acidification with 1N hydrochloric acid, and extraction with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and concentrated to give a residue which was recrystallized from petroleum ether to afford crystals of 2-hexadecanoyloxyhexadecanoic acid (5.4 g). M.p. 55°-56° C.

1. customat 0° C
2. extractionfollowed by acidification with 1N hydrochloric acid, and extraction with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customto give a residue which
7. customwas recrystallized from petroleum ether