反应详情

温度

70 °C

The product of Example 28A (5.75 g, 14.48 mmol) was dissolved in ethanol (150 mL) at room temperature and treated with sodium borohydride (1.21 g, 31.9 mmol) portionwise over 5 minutes. The solution was heated at 70° C. for 1 h and then cooled to room temperature, quenched with water, extracted into ethyl acetate, dried over sodium sulfate, and concentrated to dryness to give 4.81 g (83%) of an off-white solid.

1. temperaturecooled to room temperature
2. customquenched with water
3. extractionextracted into ethyl acetate
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated to dryness