2-Pyrrolidinemethanol, alpha,alpha-diphenyl-, (S)- → (1S,4S)-1,4-bis(4-nitrophenyl)butane-1,4-diol

Participants

Reaction Steps

The product from Example 1A (30 g, 95 wt %, 91.4 mmol) was subjected to the conditions described in Example 32, substituting (R)-(−)-α,α-diphenyl-2-pyrrolidinemethanol for (S)-(−)-α,α-diphenyl-2-pyrrolidinemethanol, to give the title compound (20.14 g, >99.55 ee, 61% yield) which was contaminated with 9.7% of the meso isomer (vs. dl isomer).

Provenance & Evidence