5-Amino-2-(trifluoromethyl)pyridine → HCID 67236518, compound

HRID 2364865Notes

Reaction equation

HRID 2364865 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8](O)[CH2:9][CH2:10][C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][CH:14]=2)O)=[CH:4][CH:3]=1.[F:21][C:22]([F:31])([F:30])[C:23]1[N:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:9][CH2:10][C@@H:11]([C:13]3[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][CH:14]=3)[N:29]2[C:26]2[CH:25]=[CH:24][C:23]([C:22]([F:31])([F:21])[F:30])=[N:28][CH:27]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27377445-Amino-2-(trifluoromethyl)pyridineHCID 59616825HCID 59616825, compound

Product 1

HCID 67236518HCID 67236518, compoundYield 10%

Procedure

The product from Example 69A (1.0 g, 2.5 mmol) was subjected to the procedure described in Example 182A, substituting 6-(trifluoromethyl)pyridin-3-amine for Example 144C, to give the title compound (0.13 g, 10%).

Sources & evidence

ORD record
ord-698a5819f56b4357995483ccba9ffc44
Source dataset
uspto-grants-2014_04
Patent number
US08691938B2

Reaction notes

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