Sodium borohydride → HCID 67236887, compound

Participants

Reaction Steps

The product from Example 191A (4.62 g, 11.65 mmole) was mixed with EtOH (100 mL) and the resulting slurry was treated in portions over a five minute period with solid NaBH4 (0.97 g, 25.6 mmole). The resulting foaming slurry was stirred and heated at reflux for 1 hr. The reaction was deemed complete by LC-MS. The reaction mixture was cooled to room temperature and concentrated in vacuo to an oily residue. The residue was dissolved in CH2Cl2 and applied to an 80 g silica gel column. The column was eluted with a gradient of hexane/acetone, 90/10 to 20/80 over 32 minutes. The fractions containing product were pooled and concentrated in vacuo giving the title compound as a white solid, 3.14 g, 67%.

Provenance & Evidence