Acetonitrile → HCID 67236398, compound

HRID 2364882Notes

Reaction equation

HRID 2364882 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]([C:16]([OH:18])=[O:17])[CH2:14][CH2:13][CH:12]2[C:19]([OH:21])=[O:20])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(#N)C>O>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C@@H:15]([C:16]([OH:18])=[O:17])[CH2:14][CH2:13][C@@H:12]2[C:19]([OH:21])=[O:20])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 67236215HCID 67236215, compound

Product 1

HCID 67236398HCID 67236398, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product from Example 214B was subjected to column chromatography on C18 silica gel using a solvent gradient of 10-60% acetonitrile in H2O (0.1% TFA). The title compound was the first of 2 major components to elute.

Sources & evidence

ORD record
ord-38116ae4310040c3b3a6c60c2c5fff9e
Source dataset
uspto-grants-2014_04
Patent number
US08691938B2

Reaction notes

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