307510-92-5 → HCID 178418274, compound

Participants

Reaction Steps

The result shown in FIG. 21 demonstrate that 8-Br-cGMP increases JV across hfRPE monolayers from 6.0 to 19.5 μl·cm−2·hr−1. This can be blocked by the addition of CFTR inhibitor CFTRinh-172, and a reduction in Jv from 19.5 to 11.5 μl·cm−2·hr−1 is observed. In four experiments, an increase in Jv from 7.4±1.1 to 15.8±1.6 μl·cm−2·hr−1 was observed, and addition of CFTR inhibitor reduced the increase in Jv to 8.9±1.3 μl·cm−2·hr−1.

Provenance & Evidence