N,N-Dimethylaniline → HCID 86653834, compound

Participants

Reaction Conditions

Reaction Steps

To 19.6 g (57.1 mmol) of 5-bromo-4,6-dihexylpyrimidin-2-ol was added 2.8 g (23 mmol) of N,N-dimethylaniline, and 40.8 g (266 mmol) of phosphoryl chloride was added under a nitrogen atmosphere, and the mixture was stirred at 100° C. for 2 hours. The resultant mixed liquid was cooled down to room temperature, then, 200 g of ice water was added, and the mixture was extracted with MTBE, washed with water and saturated saline in this order, dried over magnesium sulfate and concentrated. The resultant concentrate was purified by a silica gel column (hexane•ethyl acetate) to obtain 20.5 g (56.7 mmol) of 5-bromo-2-chloro-4,6-dihexylpyrimidine represented by the following formula:

Provenance & Evidence