Hydrochloric Acid → 2-Hydroxy-4,5-dimethoxybenzaldehyde

Participants

Reaction Steps

In a 500 mL recovery flask, 5.0 g (32.4 mmol) of 3,4-dimethoxyphenol (manufactured by Tokyo Chemical Industry Co., Ltd.) and 18.2 g (130 mmol, 4.0 eq) of hexamethylenetetramine (manufactured by Tokyo Chemical Industry Co., Ltd.) were dissolved in 100 ml of trifluoroacetic acid (manufactured by Kanto Chemical Co., Inc.) and reacted at 100° C. for 24 hours. After the reaction was completed, in an ice bath, 200 ml of 1 N hydrochloric acid was added thereto and the resultant was stirred for 15 minutes. After the stirring was completed, the resultant was extracted with chloroform to obtain an extract. The extract was washed with hydrochloric acid and saturated saline, thereby obtaining 2.17 g (11.0 mmol) of 2-hydroxy-4,5-dimethoxybenzaldehyde.

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