Dicyclohexylcarbodiimide → HCID 11184047, compound

Participants

Reaction Steps

6 g (42 mMol) (piperidine-1-yl)-acetic acid 10 was added to 4.83 g (42 mMol) N-hydroxysuccinimide and 9.53 g (46.2 mMol) dicylohexyl-carbodiimide in 100 ml CH2Cl2. The reaction mixture was stirred for 16 h at RT. The residue was filtered and the filtrate was evaporated in vacuum to dryness. The residue was then dissolved in diethylether and the solution was filtered off. The filtrate was reduced once again and the residue was dissolved in Diisopropylether. After filtration of the solution and evaporation of the solvent, the compound was then recrystallised from diisopropylether.

Provenance & Evidence