HCID 11333520, compound → 4-(Dimethylamino)butyric acid

HRID 2364935Notes

Reaction equation

HRID 2364935 reaction equation
C([O:8][C:9](=[O:16])[CH2:10][CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:14][N:13]([CH3:15])[CH2:12][CH2:11][CH2:10][C:9]([OH:16])=[O:8]

Participants

5

Reactant 2

HCID 11333520HCID 11333520, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 2398204-(Dimethylamino)butyric acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

85 g (380 mMol) 4-dimethylamino butyric acid benzylester 19 was stirred with 1 g Pd/C (5%) in 500 ml methanol. The reaction mixture was treated with hydrogen for 4 h. After removing the catalyst, methanol was distilled. A small volume of ethylacetate was added to the remaining residue so that the product would crystallise. The product was then filtered off and washed with ethylacetate.

Workup

  1. customAfter removing the catalyst, methanol
  2. distillationwas distilled
  3. additionA small volume of ethylacetate was added to the remaining residue so that the product
  4. customwould crystallise
  5. filtrationThe product was then filtered off
  6. washwashed with ethylacetate

Sources & evidence

ORD record
ord-a7ba43db5aec4fd5b4774cba6f379d0d
Source dataset
uspto-grants-2014_04
Patent number
US08697604B2

Reaction notes

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