2-Aminophenol → HCID 66726640, compound

Participants

Reaction Steps

A mixture of 2-aminophenol (2 g, 18.327 mmol), 1,4-cyclohexanedione monoethyleneketal (3.721 g, 23.825 mmol), and sodium triacetoxy-borohydride (5.826 g, 27.491 mmol) in DCE (20 ml) and acetic acid (0.2 ml) was stirred at r.t. for 3 h. The r.m. was diluted with DCM and washed with NaHCO3 aqueous saturated solution, dried (Na2SO4) and the solvent was evaporated in vacuo. The solid residue thus obtained was triturated with diisopropyl ether to yield D8 (3.78 g) as a white solid.

Provenance & Evidence