1,2-Dibromoethane → HCID 66997261, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of intermediate D10 (0.433 g, 1.319 mmol), 1,2-dibromoethane (0.341 ml, 3.958 mmol and potassium carbonate (0.912 g, 6.596 mmol) in DMF (10 ml) was heated at 180° C. for 15 min. under microwave irradiation. After cooling to r.t. the r.m. was filtered through diatomaceous earth. The filtrate was evaporated in vacuo. The crude residue was purified by column chromatography (silica gel; DCM as eluent). The desired fractions were collected and evaporated in vacuo to yield a colorless oil that crystallized to yield D12 (0.271 g, 58%).

Provenance & Evidence