HRID2365097

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12111581

未命名化合物

HCID25023015

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4cccc(C)c43)c(C)c2C1=O

HCID66608184

未命名化合物

结构：Cc1cccc2c1C(=Cc1[nH]c3c(c1C)C(=O)NCC3)C(=O)N2

HCID86660125

未命名化合物

收率 64.9%

PROCEDURE

实验过程

The title compound was prepared under the same conditions as described in Example 1 with 5-(2-diethylamino-ethyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde and 4-pyridin-4-yl-1,3-dihydro-indol-2-one (prepared according to WO2002055517) as starting materials to give 542-diethylamino-ethyl)-3-methyl-2-(4-methyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one (48 mg, 64.9%) as an orange solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5bc33f32cb094f098ae4869b0b885e66
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08697692B2
来源说明: uspto-grants-2014_04

反应 SMILES

[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][C:9]2[NH:12][C:13]([CH:16]=O)=[C:14]([CH3:15])[C:8]=2[C:7]1=[O:18])[CH3:2].N1C=C[C:24]([C:27]2[CH:35]=[CH:34][CH:33]=[C:32]3[C:28]=2[CH2:29][C:30](=[O:36])[NH:31]3)=CC=1>>[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][C:9]2[NH:12][C:13]([CH:16]=[C:29]3[C:28]4[C:32](=[CH:33][CH:34]=[CH:35][C:27]=4[CH3:24])[NH:31][C:30]3=[O:36])=[C:14]([CH3:15])[C:8]=2[C:7]1=[O:18])[CH3:2].[CH3:15][C:14]1[C:8]2[C:7](=[O:18])[NH:6][CH2:11][CH2:10][C:9]=2[NH:12][C:13]=1[CH:16]=[C:29]1[C:28]2[C:32](=[CH:33][CH:34]=[CH:35][C:27]=2[CH3:24])[NH:31][C:30]1=[O:36]