HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-Isopropylpiperazine, N1-BOC protected → (S)-4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-Isopropylpiperazine, N1-BOC protected | HCID 17750439 | — |
| Reactant | 2-[4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide | HCID 59151257 | — |
| Product | (S)-4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 59151324 | — |
Reaction Steps
Prepared using the method used in the preparation of 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide using (S)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester in place of N,N-dimethyl-2-piperazin-1-yl-isobutyramide. The title compound was obtained as an off-white solid (182 mg, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697693B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-c4f2580b89b945c382b042fa73b8daa0 |
| Source note | uspto-grants-2014_04 |