Sodium Hydroxide → HCID 67496157, compound

HRID 2365214Notes

Reaction equation

HRID 2365214 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=[N:13][N:12]([CH3:15])[C:11]=2[CH2:16][O:17][C:18]2[CH:22]=[C:21]([C:23]([O:25]C)=[O:24])[O:20][N:19]=2)=[CH:6][CH:5]=1>O1CCOCC1>[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:14]=[N:13][N:12]([CH3:15])[C:11]=2[CH2:16][O:17][C:18]2[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[O:20][N:19]=2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67497244HCID 67497244, compound

Product 1

HCID 67496157HCID 67496157, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

A solution of sodium hydroxide (2 N, 10 mL) was added dropwise to a suspension of methyl 3-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-isoxazole-5-carboxylate (460 mg, 1.38 mmol) in dioxane (20 mL) and the reaction mixture was then heated at 90° C. for 1.5 h. The reaction mixture was then evaporated and acidified with HCl (2N), and the resulting precipitate filtered off to afford the title product (320 mg, 73%) as a white solid and used directly in the next step.

Workup

  1. customThe reaction mixture was then evaporated
  2. filtrationthe resulting precipitate filtered off

Sources & evidence

ORD record
ord-054d44f908f54ca19b857e224be12e5e
Source dataset
uspto-grants-2014_04
Patent number
US08697696B2

Reaction notes

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