N-Aminomorpholine → HCID 57329854, compound

HRID 2365225Notes

Reaction equation

HRID 2365225 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[N:26]1([NH:25][C:21]([C:17]2[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]3[N:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[N:9]=[N:10][C:11]=3[CH3:24])[CH:16]=2)=[O:22])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 67495523HCID 67495523, compound

Product 1

HCID 57329854HCID 57329854, compoundYield 81%

Procedure

As described for example 3, 5-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (85 mg, 0.26 mmol), was converted, using 4-aminomorpholine instead of 4-aminotetrahydropyran, to the title compound (86 mg, 81%) which was obtained as a white solid. MS: m/e=416.3 [M+H]+.

Sources & evidence

ORD record
ord-358510b4f0d64adfa4c13fdf68fac9b0
Source dataset
uspto-grants-2014_04
Patent number
US08697696B2

Reaction notes

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