3-Amino-3-methyloxetane → HCID 57329855, compound

HRID 2365226Notes

Reaction equation

HRID 2365226 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:25][C:26]1([NH2:30])[CH2:29][O:28][CH2:27]1>>[CH3:25][C:26]1([NH:30][C:21]([C:17]2[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]3[N:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)[N:9]=[N:10][C:11]=3[CH3:24])[CH:16]=2)=[O:23])[CH2:29][O:28][CH2:27]1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 67495523HCID 67495523, compound

Product 1

HCID 57329855HCID 57329855, compoundYield 95%

Procedure

As described for example 3, 5-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (85 mg, 0.26 mmol), was converted, using 3-methyl-3-oxetanamine instead of 4-aminotetrahydropyran, to the title compound (98 mg, 95%) which was obtained as a white solid. MS: m/e=401.3 [M+H]+.

Sources & evidence

ORD record
ord-c7ac2d5762a245a2bd052402720b020c
Source dataset
uspto-grants-2014_04
Patent number
US08697696B2

Reaction notes

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