HCID 67496133, compound → HCID 67497106, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-{2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid methyl ester (204 mg, 0.54 mmol) in sulfuric acid (conc., 3.19 mL) was heated at 160° C. under Ar for 2 h. After cooling to room temperature the mixture was poured into ice and extracted with ethyl acetate and the combined organic extracts washed with brine, dried over sodium sulphate, filtered and evaporated to afford the title compound (165 mg, 88%) as an off white solid. MS: m/e=343.0 [M−H]−.

Provenance & Evidence