HCID 67496360, compound → HCID 67496330, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-{2-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid methyl ester (355 mg, 0.94 mmol) in sulfuric acid (conc, 5.9 mL) was heated at 160° C. under Ar for 30 min. After cooling to room temperature the mixture was poured into ice and extracted with ethyl acetate and the combined organic extracts washed with brine, dried over sodium sulphate, filtered and evaporated to afford the title compound (249 mg, 77%) as an grey solid. MS: m/e=345.1 [M+H]+.

Provenance & Evidence