Isopropylamine → HCID 57329856, compound

HRID 2365235Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[S:16][C:17]([C:21]([OH:23])=O)=[C:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH:25]([NH2:28])([CH3:27])[CH3:26]>>[CH:25]([NH:28][C:21]([C:17]1[S:16][C:15](/[CH:14]=[CH:13]/[C:12]2[N:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[N:9]=[N:10][C:11]=2[CH3:24])=[N:19][C:18]=1[CH3:20])=[O:23])([CH3:27])[CH3:26]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 67496330HCID 67496330, compound

Product 1

HCID 57329856HCID 57329856, compoundYield 71%

Procedure

As described for example 8c, 2-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid (72 mg, 0.21 mmol), was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (57 mg, 71%) which was obtained as an off white solid. MS: m/e=386.4 [M+H]+.

Sources & evidence

ORD record: ord-a6b6f980f3ab4b4cbf5b4515413e8533
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08697696B2

Reaction notes

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