2-Amino-4,6-dimethoxypyrimidine → HCID 13203332, compound

HRID 236528Notes

Reaction equation

HRID 236528 reaction equation
[CH3:1][C:2]1[C:3]([S:7]([N:10]=[C:11]=[O:12])(=[O:9])=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:13][C:14]1[N:19]=[C:18]([O:20][CH3:21])[CH:17]=[C:16]([O:22][CH3:23])[N:15]=1>C(#N)C>[CH3:23][O:22][C:16]1[CH:17]=[C:18]([O:20][CH3:21])[N:19]=[C:14]([NH:13][C:11]([NH:10][S:7]([C:3]2[C:2]([CH3:1])=[CH:6][S:5][CH:4]=2)(=[O:8])=[O:9])=[O:12])[N:15]=1

Participants

4

Reactant 2

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 132033314-Methyl-3-thiophenesulfonyl isocyanate

Product 1

HCID 13203332HCID 13203332, compoundYield 43.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A solution of 2 g of 4-methyl-3-thiophenesulfonyl isocyanate in 5 ml of dry acetonitrile was added to 1.5 g of 2-amino-4,6-dimethoxypyrimidine in 20 ml of acetonitrile with stirring. The mixture was stirred for 16 hours at ambient temperature and filtered to yield 1.5 g of the desired product, m.p. 175°-178°.

Workup

  1. stirringThe mixture was stirred for 16 hours at ambient temperature
  2. filtrationfiltered

Sources & evidence

ORD record
ord-bd8b79c959cb4cf496a746ede2158b54
Source dataset
uspto-grants-1987_02
Patent number
US04645529

Reaction notes

Loading…