Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 67969324, compound

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tert-Butyl 5-methyl-7-(2-oxo-4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (72 mg, 0.14 mmol) was deprotected and converted to the dihydrochloride salt according to Example 2 (step g) to provide the title compound (32 mg, 46%) as an off-white solid: 1H NMR (500 MHz, DMSO-d6) δ 9.15 (s, 2H), 8.49 (s, 1H), 7.90-7.88 (dd, J=9.1, 2.5 Hz, 1H), 7.49 (d, J=6.6 Hz, 1H), 7.48 (s, 1H), 7.04-7.00 (dd, J=8.4, 1.7 Hz, 1H), 7.01 (d, J=9.0 Hz, 1H), 4.39 (s, 2H), 4.35-4.30 (m, 2H), 4.08-4.04 (m, 2H), 3.91-3.88 (m, 2H), 3.65 (s, 3H), 3.54-3.40 (m, 3H), 3.09-3.04 (m, 2H); ESI MS m/z 430 [M+H]+; HPLC (Method B) 99% (AUC), tR=14.4 min.

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