4-Phenethylpiperazin-2-one → tert-Butyl 5-methyl-7-(2-oxo-4-phenethylpiperazin-1-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Participants

Reaction Steps

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (370 mg, 1.01 mmol) and 4-phenethylpiperazin-2-one (197 mg, 0.965 mmol) were reacted according to Example 2 (step f) to provide the title compound (180 mg, 39%) as a yellow powder: 1H NMR (300 MHz, CDCl3) δ 7.48 (d, J=8.4 Hz, 1H), 7.35-7.28 (m, 2H), 7.27-7.18 (m, 4H), 6.99-6.97 (dd, J=8.3, 1.8 Hz, 1H), 4.61 (br s, 2H), 3.74 (br s, 4H), 3.60 (s, 3H), 3.45 (br s, 2H), 2.91 (br s, 4H), 2.74 (br s, 4H), 1.50 (s, 9H).

Provenance & Evidence