tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate → tert-Butyl 5-methyl-7-(2-oxo-4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Participants

Reaction Steps

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (280 mg, 0.761 mmol) and 4-(2-(pyridin-2-yl)ethyl)piperazin-2-one (156 mg, 0.760 mmol) were reacted according to Example 2 (step f) to provide the title compound (210 mg, 56%) as a yellow oil: ESI MS m/z 490 [M+H]+.

Provenance & Evidence