HRID2365403

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8547165

未命名化合物

结构：Cc1ccc(S(=O)(=O)n2c3c(c4ccc(Br)cc42)CN(C(=O)OC(C)(C)C)CC3)cc1

HCID57950411

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)n2c3c(c4ccc(N5CCN(CCc6ccccc6)CC5=O)cc42)CN(C(=O)OC(C)(C)C)CC3)cc1

HCID67986824

未命名化合物

收率 60.1%

PROCEDURE

实验过程

tert-Butyl 7-bromo-5-tosyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (600 mg, 1.19 mmol) and 4-phenethylpiperazin-2-one (266 mg, 1.30 mmol) were reacted according to Example 2 (step f) to provide the title compound (450 mg, 60%) as a white powder: ESI MS m/z 629 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c4777f18f6204753905697fd28390cee
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08697700B2
来源说明: uspto-grants-2014_04

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:24][N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:22][CH2:21][C:7]=3[N:8]([S:11]([C:14]3[CH:20]=[CH:19][C:17]([CH3:18])=[CH:16][CH:15]=3)(=[O:13])=[O:12])[C:9]=2[CH:10]=1.[CH2:32]([N:40]1[CH2:45][CH2:44][NH:43][C:42](=[O:46])[CH2:41]1)[CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[O:46]=[C:42]1[CH2:41][N:40]([CH2:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:45][CH2:44][N:43]1[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:24][N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:22][CH2:21][C:7]=3[N:8]([S:11]([C:14]3[CH:20]=[CH:19][C:17]([CH3:18])=[CH:16][CH:15]=3)(=[O:13])=[O:12])[C:9]=2[CH:10]=1