4-(4-Fluorophenethyl)piperazin-2-one → tert-Butyl 7-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Fluorophenethyl)piperazin-2-one	HCID 57514761	—
Reactant	tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate	HCID 57950375	—
Product	tert-Butyl 7-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate	HCID 67986820	33.5%

Reaction Steps

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (1.6 g, 4.4 mmol) and 4-(4-fluorophenethyl)piperazin-2-one (0.96 g, 4.3 mmol) were reacted according to Example 2 (step f) to provide the title compound (730 mg, 33%) as a yellow powder: ESI MS m/z 507 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08697700B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-585a89aa9a5a4acf9326819bb93641f2
Source note	uspto-grants-2014_04