HRID2365410

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57514761

未命名化合物

结构：CC1Cc2c(c3ccc(Br)cc3n2C)CN1C(=O)OC(C)(C)C

HCID67986822

未命名化合物

PRODUCTS

生成物

结构：CC1Cc2c(c3ccc(N4CCN(CCc5ccc(F)cc5)CC4=O)cc3n2C)CN1C(=O)OC(C)(C)C

HCID67986823

未命名化合物

收率 67%

PROCEDURE

实验过程

tert-Butyl 7-bromo-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (300 mg, 0.791 mmol) and 4-(4-fluorophenethyl)piperazin-2-one (174 mg, 0.791 mmol) were reacted following the procedure for Example 2 (step f) to provide the title compound (275 mg, 67%) as a yellow oil: ESI MS m/z 521 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1aa8c0fd4fe6485d8e8377b69ef70429
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08697700B2
来源说明: uspto-grants-2014_04

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:13]([CH3:23])[CH2:12][C:7]=3[N:8]([CH3:11])[C:9]=2[CH:10]=1.[F:24][C:25]1[CH:39]=[CH:38][C:28]([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][NH:34][C:33](=[O:37])[CH2:32]2)=[CH:27][CH:26]=1>>[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][N:34]([C:2]3[CH:3]=[CH:4][C:5]4[C:6]5[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:13]([CH3:23])[CH2:12][C:7]=5[N:8]([CH3:11])[C:9]=4[CH:10]=3)[C:33](=[O:37])[CH2:32]2)=[CH:38][CH:39]=1