Water → tert-Butyl 7-bromo-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Participants

Reaction Steps

tert-Butyl 7-bromo-3-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (enantiomer A) (1.00 g, 2.73 mmol) was dissolved in DMF (10 mL), and NaH (60% disp, 131 mg, 3.28 mmol) was added. After stirring for 30 minutes, MeI (386 mg, 0.170 ml, 3.28 mmol) was added, and the reaction continued for 1 h. The mixture was poured into water (250 ml), and the solid was filtered off to provide the title compound (180 mg, 17%) as a yellow solid: ESI MS m/z 379 [M+H]+.

Provenance & Evidence