4-(4-Fluorophenethyl)piperazin-2-one → tert-Butyl 7-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Fluorophenethyl)piperazin-2-one	HCID 57514761	—
Reactant	tert-Butyl 7-bromo-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate	HCID 67986822	—
Product	tert-Butyl 7-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate	HCID 67986823	58%

Reaction Steps

tert-Butyl 7-bromo-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (enantiomer A) (180 mg, 0.474 mmol) and 4-(4-fluorophenethyl)piperazin-2-one (104 mg, 0.474 mmol) were reacted following the procedure for Example 2 (step f) to provide the title compound (144 mg, 58%) as a yellow solid: ESI MS m/z 521 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08697700B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-7f06e2fbf3fd4aee832ccfaf4cf76047
Source note	uspto-grants-2014_04