HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methoxy-N-methyl-1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide → 2-(3-chlorophenyl)-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methoxy-N-methyl-1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | HCID 86707831 | — |
| Reactant | HCID 178478996 | HCID 178478996 | — |
| Product | 2-(3-chlorophenyl)-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone | HCID 68296338 | 94% |
Reaction Steps
This compound was prepared by the reaction of 3-chlorobenzylmagnesium chloride (0.25 M solution in diethyl ether) with N-methoxy-N-methyl-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide as described in General Method 1. The desired compound was obtained in 94% yield as a viscous clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697697B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-1156817d0c09488796b1f4a4bfaba64b |
| Source note | uspto-grants-2014_04 |