(2-Aminoethoxy)(tert-butyl)dimethylsilane → HCID 136338083, compound

HRID 2365431Notes

Reaction equation

HRID 2365431 reaction equation
C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.Cl[C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=1)[C:29](O)=O.[C:35]1([C:41]2[CH:45]=[N:44][NH:43][C:42]=2[C:46]2[C:54]3[C:49](=[N+:50]([O-])[CH:51]=[CH:52][CH:53]=3)[NH:48][CH:47]=2)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.[Si:56]([O:63][CH2:64][CH2:65][NH2:66])([C:59]([CH3:62])([CH3:61])[CH3:60])([CH3:58])[CH3:57]>>[CH2:29]([N:66]([CH2:65][CH2:64][O:63][Si:56]([C:59]([CH3:62])([CH3:61])[CH3:60])([CH3:58])[CH3:57])[C:51]1[N:50]=[C:49]2[NH:48][CH:47]=[C:46]([C:42]3[NH:43][N:44]=[CH:45][C:41]=3[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:54]2=[CH:53][CH:52]=1)[C:28]1[CH:32]=[CH:33][CH:34]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 529218(2-Aminoethoxy)(tert-butyl)dimethylsilaneHCID 2733179PyBroPHCID 178524355HCID 178524355, compound

Product 1

HCID 136338083HCID 136338083, compound

Procedure

This material was synthesized by the PyBrOP mediated amination of 3-(4-phenyl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine 7-oxide meta-chlorobenzoate salt with 2-((tert-butyldimethylsilyl)oxy)ethylamine as described in Step 2 of Example 4. The crude product obtained was used directly in Step 2 below.

Sources & evidence

ORD record
ord-2c02cc3842e947099920964a72aeda7c
Source dataset
uspto-grants-2014_04
Patent number
US08697697B2

Reaction notes

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