Hydrochloric Acid → HCID 136138789, compound

Participants

Reaction Steps

The title compound was synthesized by the hydrogen chloride mediated deprotection of N-benzyl-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-3-(4-phenyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine as described in Step 2 of Example 5. Purification by preparative TLC then preparative HPLC, followed by salt formation with 2N HCl/MeOH and final isolation by lyophilization from water afforded 2-{benzyl-[3-(4-phenyl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl]-amino}ethanol dihydrochloride in 10% overall yield as a yellow solid.

Provenance & Evidence