Carbon Dioxide → HCID 67323561, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-bromo-2-methylquinoline (400 mg, supplier Bioblocks Inc.) in THF (8 mL) under argon at −78° C. was added n-butyllithium (0.865 mL) dropwise. The reaction was stirred for 15 minutes at −78° C. before it was poured onto solid carbon dioxide in a beaker. The mixture was swirled until warmed to room temperature to prevent bumping, then the solvent was removed in vacuo to give the crude title compound (404 mg), which was used directly in subsequent reactions.

Provenance & Evidence