1-Boc-D-Pyroglutamic acid ethyl ester → HCID 67086647, compound

HRID 2365537Notes

Reaction equation

HRID 2365537 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9](C)[CH2:10][CH2:11][CH:12]([NH2:15])[CH2:13][NH2:14])=[CH:5][CH:4]=1.C(N1C(=O)CC[C@@H]1C(OCC)=O)(OC(C)(C)C)=O.C(N1C(=O)CC[C@H]1C(OCC)=O)(OC(C)(C)C)=O>>[NH2:15][C@H:12]([CH2:13][NH2:14])[CH2:11][CH2:10][CH2:9][C:6]1[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 8208851-Boc-D-Pyroglutamic acid ethyl esterHCID 54611861-(1,1-Dimethylethyl) 2-ethyl (2S)-5-oxo-1,2-pyrrolidinedicarboxylateHCID 67086733HCID 67086733, compound

Product 1

HCID 67086647HCID 67086647, compound

Procedure

This compound is prepared analogously to Intermediate K (NVP-QBM333), replacing Ethyl Boc-D-pyroglutamate in step 1 with Ethyl Boc-L-pyroglutamate; [M+H]+ 195

Sources & evidence

ORD record
ord-e9d0ac2b9a5c4c048583f536f49ea566
Source dataset
uspto-grants-2014_04
Patent number
US08697687B2

Reaction notes

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