HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2365544Generated: October 30, 2026
Ammonia → tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate
https://huagongshe.com/reaction/2365544
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Aminomethyl-4-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86641911 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate | HCID 22975818 | — |
Reaction Steps
To a solution of 4-aminomethyl-4-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester in MeOH (70 ml) is added a 30% aqueous solution of ammonia (70 ml) and the reaction mixture is stirred at 80° C. overnight. The reaction mixture is concentrated in vacuo to 4-Amino-4-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester as a brown oil that is used crude without further purification; [M+H]+ 230.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08697687B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-7993df4947504d45a4c89791662e599f |
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| Source note | uspto-grants-2014_04 |
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