Methyl 4-aminobenzoate → 4-(((Propan-2-yl)carbamoyl)amino)benzoic acid

HRID 2365550Notes

Reaction equation

HRID 2365550 reaction equation
[CH:1]([NH:4][C:5](=[O:16])[NH:6][C:7]1C=C(C=CN=1)C(O)=O)([CH3:3])[CH3:2].N[C:18]1[CH:19]=[C:20]([CH:26]=[CH:27]N=1)[C:21]([O:23]CC)=[O:22].NC1C=CC(C(OC)=O)=CC=1>>[CH:1]([NH:4][C:5](=[O:16])[NH:6][C:7]1[CH:18]=[CH:19][C:20]([C:21]([OH:23])=[O:22])=[CH:26][CH:27]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 12082Methyl 4-aminobenzoateHCID 7015521Ethyl 2-aminopyridine-4-carboxylateHCID 643934662-(3-Isopropyl-ureido)-isonicotinic acid

Product 1

HCID 142463564-(((Propan-2-yl)carbamoyl)amino)benzoic acid

Procedure

This compound is prepared analogously to Intermediate Y by replacing ethyl 2-aminoisonicotinate in step 1 with methyl 4-aminobenzoate; [M+H]+ 237.

Sources & evidence

ORD record
ord-0ac0129f005f4dc091dad4396eec7bbd
Source dataset
uspto-grants-2014_04
Patent number
US08697687B2

Reaction notes

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