反应详情

A solution of 3-(Cyclohexyl-methyl-sulfamoyl)-4-methoxy-benzoic acid methyl ester (1.50 g, 4.39 mmol) in 1,4 dioxane (40 ml) is treated with 2 N NaOH (10 ml) and the resulting solution is stirred at room temperature for 21 hours. The solvent is removed in vacuo and ice cold 2 N HCl (25 ml) is added and the white solid which forms is extracted into DCM (150 ml). The organic layer is washed with water, dried (MgSO4) and the solvent removed in vacuo to yield the title compound as a white solid; [M−1]+ 326.

1. customThe solvent is removed in vacuo and ice cold 2 N HCl (25 ml)
2. additionis added
3. extractionthe white solid which forms is extracted into DCM (150 ml)
4. washThe organic layer is washed with water
5. dry with materialdried (MgSO4)
6. customthe solvent removed in vacuo