HCID 20216272, compound → HCID 20216264, compound

Participants

Reaction Steps

21.7 g. of α-ethinyl-α-(2,4-dichlorophenyl)-4-[3-(dipropylamino)-propoxy]-benzylalcohol are dissolved in 210 ml. of benzene, and the solution is hydrogenated in the presence of 1.1 g. of a 10% palladium-on-charcoal catalyst. When the uptake of the calculated amount of hydrogen is complete (about 3 hours), catalyst is filtered off and benzene is distilled off. The crude product weighing 21 g. is distilled in vacuo, to yield a product boiling at 194° to 196° C./6.6 Pa.

Provenance & Evidence