Thiomorpholine → HCID 59625692, compound

HRID 2365692Notes

Reaction equation

HRID 2365692 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH:16]1[CH2:21][CH2:20][S:19][CH2:18][CH2:17]1>CO>[S:19]1[CH2:20][CH2:21][N:16]([C:2]2[C:11]3[C:6](=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 17750389Methyl 4-chloroquinazoline-7-carboxylate

Product 1

HCID 59625692HCID 59625692, compoundYield 10.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 4-chloroquinazoline-7-carboxylate 66a (1.01 mmol, 225 mg) and thiomorpholine 66b (2.02 mmol, 208 mg) in MeOH (1.6 mL) was refluxed overnight. Compound 66c (30 mg) was isolated after purification.

Sources & evidence

ORD record
ord-f174b104826744d18204f24b319564cf
Source dataset
uspto-grants-2014_04
Patent number
US08697683B2

Reaction notes

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