HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-{3-[2-(2-Methoxyethoxy)ethoxy]phenyl}-2-(methylamino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-{3-[2-(2-Methoxyethoxy)ethoxy]phenyl}oxirane | HCID 22574382 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-{3-[2-(2-Methoxyethoxy)ethoxy]phenyl}-2-(methylamino)ethanol | HCID 10214689 | — |
Reaction Steps
A solution of 1.78 g of 2-{3-[2-(2-methoxyethoxy)ethoxy]phenyl}oxirane in 30 ml of 2.0 M methylamine in methanol is stirred at room temperature overnight, then concentrated under reduced pressure. Flash chromatography of the residue on silica using 5-7% methanolic ammonia in CH2Cl2 affords 809 mg of the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06852731B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-bb509f1b8640430d8cc33626b71a7076 |
| Source note | uspto-grants-2005_02 |