Sodium Methoxide → HCID 13564992, compound

Participants

Reaction Steps

1 g of β-acetoxy-ethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-benzyloxyphenyl)-pyridine-5-carboxylate is suspended in 120 ml of absolute methanol, and 2 ml of 1 molar sodium methylate solution are added, a dark red solution soon being formed. When the reaction has ended (check by thin layer chromatography), the mixture is rendered neutral with Amberlite IR 120 H⊕ and filtered and the filtrate is concentrated. The solid evaporation residue is stirred with ethanol and filtered off with suction. 600 mg (65.8% of theory) of a yellow-colored compound of melting point 183°-185° C. are obtained.

Provenance & Evidence