HCID 67345140, compound → HCID 24854974, compound

HRID 2365783Notes

Reaction equation

HRID 2365783 reaction equation
[Br:1][C:2]1[C:3]([O:12][CH2:13][CH2:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[C:4]([CH:7]=[C:8]([S:10][CH3:11])[CH:9]=1)[CH:5]=O.Cl.[NH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]1[NH:32][C:31]2[CH:33]=[CH:34][S:35][C:30]=2[C:29](=[O:36])[CH:28]=1>>[Br:1][C:2]1[C:3]([O:12][CH2:13][CH2:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[C:4]([CH:7]=[C:8]([S:10][CH3:11])[CH:9]=1)[CH2:5][NH:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]1[NH:32][C:31]2[CH:33]=[CH:34][S:35][C:30]=2[C:29](=[O:36])[CH:28]=1

Participants

3

Reactant 2

HCID 67345140HCID 67345140, compoundHCID 86623231HCID 86623231, compound

Product 1

HCID 24854974HCID 24854974, compound

Procedure

5-{3-[3-Bromo-5-methylsulfanyl-2-(2-pyridin-3-yl-ethoxy)-benzylamino]-propylamino}-4H-thieno[3,2-b]pyridin-7-one was prepared by reductive amination of the aldehyde prepared in Example 2 with amine XVIII following method C, Scheme 1.

Sources & evidence

ORD record
ord-93597c4c696840bc9c654eb01433ef49
Source dataset
uspto-grants-2014_04
Patent number
US08697720B2

Reaction notes

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