HCID 68610203, compound → HCID 46214206, compound

HRID 2365913Notes

Reaction equation

HRID 2365913 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15]CC2C=CC=CC=2)[CH:12]=[CH:11][C:10]=1[CH:23]1[CH2:28][CH2:27][N:26]([C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:30])[CH2:25][CH2:24]1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:14]=[C:13]([OH:15])[CH:12]=[CH:11][C:10]=1[CH:23]1[CH2:24][CH2:25][N:26]([C:29]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:30])[CH2:27][CH2:28]1

Participants

4

Reactant 1

HCID 68610203HCID 68610203, compound

Product 1

HCID 46214206HCID 46214206, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a 25 ml round-bottomed flask, 0.5 g of [4-(2,4-bis(benzyloxy)phenyl)piperidin-1-yl]phenylmethanone is dissolved in 15 ml of methanol in the presence of 0.2 g of palladium-on-charcoal at 10%. The reaction mixture is stirred for 48 hours under a hydrogen atmosphere. The reaction mixture is filtered and the residue is then chromatographed on silica gel (1/1 heptane/ethyl acetate).

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe residue is then chromatographed on silica gel (1/1 heptane/ethyl acetate)

Sources & evidence

ORD record
ord-8057831e40a74f3bb88681ea3cfa5bbc
Source dataset
uspto-grants-2014_04
Patent number
US08697726B2

Reaction notes

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