Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| Reactant | 3-(4-Chlorophenyl)piperidine | HCID 20364575 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 25174675 | HCID 25174675 | 69.8% |
Reaction Steps
A mixture of 2-bromomethyl-2,3-dihydrobenzo[1,4]dioxine (34 mg, 0.15 mmol), 3-(4-chloro-phenyl)piperidine (38 mg, 0.165 mmol) and triethylamine (38 mg, 0.38 mmol) in acetonitrile (2 ml) was heated in a microwave reactor at 110-150° C. for 290 min. After evaporation to dryness, the crude product was purified by flash chromatography using a gradient of heptane and EtOAc as eluent to give 36 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08697723B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-5c659a4f74a44df19d7f10440690f8bc |
|---|
| Source note | uspto-grants-2014_04 |
|---|
