HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-trifluoromethylphenyl)-piperidin-1-yl]methanone → (S*)-1-[(S)-1-(2,3-Dihydrobenzo[1,4]dioxin-2-yl)methyl]-3-(4-trifluoromethylphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-trifluoromethylphenyl)-piperidin-1-yl]methanone | HCID 66727248 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S*)-1-[(S)-1-(2,3-Dihydrobenzo[1,4]dioxin-2-yl)methyl]-3-(4-trifluoromethylphenyl)piperidine | HCID 25174839 | 48.2% |
Reaction Steps
(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-trifluoromethylphenyl)piperidin-1-yl]methanone (13 mg, 0.033 mmol) was treated with BH3 THF according to the above general procedure. Flash chromatography gave 6 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697723B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-b83b52d201734e61b6d84fd85bb46f59 |
| Source note | uspto-grants-2014_04 |