HCID 25175496, compound → HCID 25175497, compound

HRID 2365980Notes

Reaction equation

HRID 2365980 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:21][CH2:20][C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[CH2:13]1>CO>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:21][CH2:20][CH:19]2[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]2)[CH2:13]1

Participants

3

Reactant 1

HCID 25175496HCID 25175496, compound

Product 1

HCID 25175497HCID 25175497, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The above described 2-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-1,2,3,4,5,6,7,8-octahydroiso-quinoline (195 mg, 0.68 mmol) was hydrogenated in MeOH (20 ml) under normal pressure (12 h, 50° C.) to give the crude title compound, which was purified by flash chromatography (heptane/EtOAc).

Sources & evidence

ORD record
ord-eb673b7333b647f08dcecc01cdfde91b
Source dataset
uspto-grants-2014_04
Patent number
US08697723B2

Reaction notes

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