Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2366048생성일: 2026년 10월 25일
Hydrochloric Acid → 1-[(S)-1-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)methyl]-3-(2-methoxy-phenyl)-pyrrolidine
https://huagongshe.com/reaction/2366048
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl 4-methylbenzenesulfonate | HCID 7101148 | — |
| 반응물 | 3-(2-Methoxyphenyl)pyrrolidine | HCID 15029963 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-[(S)-1-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)methyl]-3-(2-methoxy-phenyl)-pyrrolidine | HCID 66727177 | — |
반응 단계
Toluene-4-sulfonic acid (R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl ester (0.156 mmol), 3-(2-methoxyphenyl)pyrrolidine.HCl (1.55 mmol, 32 mg), K2CO3 (0.342 mmol, 47 mg) and acetonitrile (1 ml) were mixed and heated in a microwave reactor at 120° C. for 2.5 h. The reaction mixture was filtrated and the solution was absorbed on silica. Flash chromatography, using a gradient of heptane/EtOAc as eluent, gave 20 mg g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08697723B2 |
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| 출처 데이터셋 | uspto-grants-2014_04 |
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| ORD ID | ord-95bc85577bc642cca1334a110e92c34f |
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| 출처 메모 | uspto-grants-2014_04 |
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